Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy     

Yixin Hu  Aili Chen  Xinchang Zheng  Jun Lu  Hailong He  Jin Yang  Ya Zhang  Pinpin Sui  Jingyi Yang  Fuhong He  Yi Wang  Peifang Xiao  Xin Liu  Yinmei Zhou  Deqing Pei  Cheng Cheng  Raul C Ribeiro  Shaoyan Hu  Qian-fei Wang 《国家科学评论(英文版)》2019,6(3):469

Standard chemotherapy regimens for remission induction of pediatric acute myeloid leukemia (AML) are associated with significant morbidity and mortality. We performed a cohort study to determine the impact of reducing the intensity of remission induction chemotherapy on the outcomes of selected children with AML treated with a low-dose induction regimen plus granulocyte colony stimulating factor (G-CSF) (low-dose chemotherapy (LDC)/G-CSF). Complete response (CR) after two induction courses was attained in 87.0% (40/46) of patients receiving LDC/G-CSF. Post-remission therapy was offered to all patients, and included standard consolidation and/or stem cell transplantation. During the study period, an additional 94 consecutive children with AML treated with standard chemotherapy (SDC) for induction (80/94 (85.1%) of the patients attained CR after induction II, P = 0.953) and post-remission. In this non-randomized study, there were no significant differences in 4-year event-free (67.4 vs. 70.7%; P = 0.99) and overall (70.3 vs. 74.6%, P = 0.69) survival in the LDC/G-CSF and SDC cohorts, respectively. After the first course of induction, recovery of white blood cell (WBC) and platelet counts were significantly faster in patients receiving LDC/G-CSF than in those receiving SDC (11.5 vs. 18.5 d for WBCs (P < 0.001); 15.5 vs. 22.0 d for platelets (P < 0.001)). To examine the quality of molecular response, targeted deep sequencing was performed. Of 137 mutations detected at diagnosis in 20 children who attained hematological CR after two courses of LDC/G-CSF (n = 9) or SDC (n = 11), all of the mutations were below the reference value (variant allelic frequency <2.5%) after two courses, irrespective of the treatment group. In conclusion, children with AML receiving LDC/G-CSF appear to have similar outcomes and mutation clearance levels, but significantly lower toxicity than those receiving SDC. Thus, LDC/G-CSF should be further evaluated as an effective alternative to remission induction in pediatric AML.  相似文献   

棱镜折射：网络舆情的生成逻辑与内容层次 ——基于 “出租车罢运事件”的扎根理论分析          下载免费PDF全文

田进  张明垚 《情报科学》2019,37(8):38-43

【目的/意义】针对频繁爆发的网络舆情,深度梳理网络舆情的内容层次,挖掘网络舆情的生成逻辑,为政府 网络舆情治理提供可行路径。【方法/过程】以“2015年初出租车罢运事件”作为研究案例,通过网络数据抓取软件收 集“财经网”相关微博下的评论信息,按照扎根理论的编码程序逐步抽象形成网络舆情的“棱镜折射”生成逻辑和 “情绪—态度—意见、行为取向”的内容层次。【结论/结果】研究结果显示,网络舆情的基本层次是网民情绪,网络舆 情的生成由公共事件的相关新闻信息触发,并取决于网民的生活经历、角色定位、思维方式、信息处理等个人特 征。因此,政府的网络舆情治理应重点关注网民情绪,并强化与网民的对话沟通和信息普及。  相似文献   

作者-主题关联的学科知识网络构建与演化分析          下载免费PDF全文

何劲  关鹏  王曰芬 《情报科学》2019,37(1):56

【目的/意义】通过构建作者-主题关联的二模学科知识网络,度量作者在知识创新网络中的影响力,探寻 研究活跃程度高、研究范围广、潜在合作空间大的重要学者,对于科学评价学者学术影响力,挖掘热点、前沿研究主 题具有重要的指导作用。【方法/过程】基于AT主题模型抽取作者-主题关联矩阵,计算作者的研究主题强度,在此 基础上构建作者-主题关联的二模学科知识网络,利用作者在网络中的中心性指标度量作者主题关联影响力;基于 复杂网络结构分析方法对学科领域生命周期内作者-主题关联的学科知识网络进行演化分析。【结果/结论】实证分 析表明作者主题关联影响力与基于引文的学术影响力和基于社交媒体的社会影响力指标形成有力互补,可用于核 心作者以及热点、前沿主题探测。  相似文献   

修订后的《档案著录规则》之新特点     

方威明  孙瑾 《山西档案》2001,(5):15-17

本通过对新颁布的《档案录规则》（DA/T18-1999）和原《档案录规则》（GB3792.5-85）的比较，从中归纳出新《档案录规则》的新特点。  相似文献   

Assessing volunteer satisfaction at the London Olympic Games and its impact on future volunteer behaviour     

Minhong Kim  Steven Suk-Kyu Kim  May Kim  James J. Zhang 《Sport in Society》2019,22(11):1864-1881

Abstract

In recent years, volunteering has received strong research attention from both scholars and practitioners. For the most part, involvement in volunteer activities has been identified as an important determinant of future volunteering. Through revalidating an existing instrument, the purpose of this study was to assess the dimensions of volunteer satisfaction at the 2012 London Olympic Games and its impact on future volunteer behaviour. The findings of this study shed light on the identification of volunteer satisfaction factors in the mega sporting event setting, particularly for a unique type of volunteer (i.e. media worker) assigned to a special set of tasks. Unlike Galindo-Kuhn and Guzley’s results that revealed participation efficacy and group integration to be strong predictors of volunteer satisfaction, organizational support was the primary predictor for media centre volunteers’ re-participation intention towards future volunteering programmes.  相似文献   

Platform War vs. Platform Synergy? A Longitudinal Analysis of Media Substitution between Personal Computers and Mobile Devices     

Su Jung Kim  Vijay Viswanathan  Hye Mi Lee 《广播与电子媒介杂志》2020,64(2):65-88

ABSTRACT

Research on media substitution theory has examined substitutional and/or complementary relationships between new and existing media. This study focuses on the growth of mobile platforms and investigates the relationship between mobile devices and personal computers. Using Nielsen’s panel data that provide electronically recorded media usage (N = 2,396), this study analyzes yearly changes in time allocation to mobile devices and PCs at total and content-specific usage levels during mobile 4G transition. Results suggest a complementarity dynamic between mobile devices and PCs; however, the patterns were more nuanced in light of the role of individual and structural factors when determining media choice.  相似文献   

江苏省马拉松认证赛事空间分布及影响因素研究     

王进 《南京体育学院学报(社会科学版)》2020,34(6):19-27

研究选取江苏省41场马拉松认证赛事为研究样本，运用最邻近点指数、地理集中指数、地理联系率、核密度指数等方法研究马拉松认证赛事的分布规律及影响因素。结果表明：①江苏省马拉松认证赛事整体空间分布趋于集聚，空间结构属于凝聚型；②不同类型马拉松认证赛事中，半程马拉松认证赛事集聚程度高，全程马拉松、16 km、10 km和5 km马拉松认证赛事布局分散；③经济基础、教育程度、景点资源和产业发展是影响特马拉松认证赛事分布的主要因素。  相似文献   

形成性评估应用于大学英语听力教学的绩效研究     

金飞  许丽芹 《池州学院学报》2020,(1):135-138

实验研究得知,相较于终结性评估,形成性评估应用于大学英语听力教学不仅能够更为有效地激发和提高学生的学习动力,而且更能有效地提升听力学习绩效;形成性评估更能激发学生的听力学习自主性和合作性,提高其听力自主学习能力和合作学习能力.形成性评估能促使教师转变教学方式,改进听力教学,对提高教学质量和教学绩效有一定的意义.  相似文献   

公共健康视角下的电子竞技发展趋势研究     

闫金 《山东体育科技》2020,(1):11-15

电子竞技(E-sports)已经成为当代发展最快,且最重要的文化现象之一。国家体育总局于2003年将它列为第99个运动项目,又在2011年再次将电子竞技改为正式比赛项目。电子竞技从运动员、观众和经济价值而言,是一个不断发展的产业,而且它将被列入2024年巴黎奥运会。虽然最初主要是年轻男性对电子竞技感兴趣,但电子竞技有可能在更广泛的用户群体中带来健康行为的改变。本文运用文献资料法,对比分析法和逻辑分析法探讨电子竞技在整个生命周期内影响健康行为以及一些主要困境的解决措施。除此之外,电子竞技将有可能帮助于个人改变其体育活动和健康行为。最后考虑到电子竞技的指数增长,对于学者和政策制定者来说,认识到电子竞技带来的机遇是非常重要的。  相似文献   

Difference score reliabilities within the RIAS-2 and WISC-V     

Ryan L. Farmer  Samuel Y. Kim 《Psychology in the schools》2020,57(8):1273-1288

Many prominent intelligence tests (e.g., Wechsler Intelligence Scale for Children, Fifth Edition [WISC-V] and Reynolds Intellectual Abilities Scale, Second Edition [RIAS-2]) offer methods for computing subtest- and composite-level difference scores. This study uses data provided in the technical manual of the WISC-V and RIAS-2 to calculate reliability coefficients for difference scores. Subtest-level difference score reliabilities range from 0.59 to 0.99 for the RIAS-2 and from 0.53 to 0.87 for the WISC-V. Composite-level difference score reliabilities generally range from 0.23 to 0.95 for the RIAS-2 and from 0.36 to 0.87 for the WISC-V. Emphasis is placed on comparisons recommended by test publishers and a discussion of minimum requirements for interpretation of differences scores is provided.  相似文献